Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa.

ABSTRACT:

Objective

We developed the Healthy Families-PrEP intervention to support HIV-prevention during periconception and pregnancy. We evaluated preexposure prophylaxis (PrEP) use with three objective measures.

Design

This single-arm intervention study enrolled women in KwaZulu-Natal, South Africa, who were HIV-uninfected, not pregnant, in a relationship with a partner with HIV or unknown-serostatus, and with pregnancy plans. PrEP was offered as part of a comprehensive HIV prevention intervention. Participants were followed for 12 months.

Methods

We evaluated periconception PrEP uptake and adherence using quarterly plasma tenofovir concentrations. We modeled factors associated with PrEP uptake and high plasma tenofovir (past day dosing). Patterns of use were analyzed using e

SUBMITTER: Matthews LT 

PROVIDER: S-EPMC11211057 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature