Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.

ABSTRACT:

Objective

The main objective of this study is to better understand the effects of diet-induced weight loss on brain connectivity in response to changes in glucose levels in individuals with obesity.

Methods

A total of 25 individuals with obesity, among whom 9 had a diagnosis of type 2 diabetes, underwent functional magnetic resonance imaging (fMRI) scans before and after an 8-week low-calorie diet. We used a two-step hypereuglycemia clamp approach to mimic the changes in glucose levels observed in the postprandial period in combination with task-mediated fMRI intrinsic connectivity distribution (ICD) analysis.

Results

After the diet, participants lost an average of 3.3% body weight. Diet-induced weight loss led to a decrease in leptin levels, an increase in hunger and

SUBMITTER: Hoang H 

PROVIDER: S-EPMC11211061 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature