Causal relationship between inflammatory skin diseases and breast cancer: A bidirectional Mendelian randomization study.

ABSTRACT:

Introduction

Prior research has explored the relationship between inflammatory skin disorders and breast cancer (BC), yet the causality of this association remains uncertain.

Methods

Utilizing a bidirectional two-sample Mendelian randomization (MR) approach, this study aimed to elucidate the causal dynamics between various inflammatory skin conditions-namely acne, atopic dermatitis, psoriasis vulgaris, urticaria, and rosacea-and BC. Genetic variants implicated in these disorders were sourced from comprehensive genome-wide association studies representative of European ancestry. In the forward MR, BC was posited as the exposure, while the reverse MR treated each inflammatory skin disease as the exposure. A suite of analytical methodologies, including random effects inverse va

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11211090 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature