Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects.

ABSTRACT: Schizophrenia significantly impacts cognitive and behavioral functions and is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which can diminish patient compliance, worsen psychiatric symptoms and increase cardiovascular disease risk. This study explores the hypothesis that SGAs affect the molecular determinants of synaptic plasticity and brain activity, particularly focusing on the lateral septum (LS) and its interactions within hypothalamic circuits that regulate feeding and energy expenditure. Utilizing functional ultrasound imaging, RNA sequencing, and weighted gene co-expression network analysis, we identified significant alterations in the functional connection between

SUBMITTER: Huang L 

PROVIDER: S-EPMC11211371 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature