Distributable, metabolic PET reporting of tuberculosis.

ABSTRACT: Tuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of disease activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum which limits sampling to organisms on the pulmonary surface. Advances in monitoring tuberculous lesions have utilized the common glucoside [¹⁸F]FDG, yet lack specificity to the causative pathogen Mycobacterium tuberculosis (Mtb) and so do not directly correlate with pathogen viability. Here we show that a close mimic that is also positron-emitting of the non-mammalian Mtb disaccharide trehalose - 2-[¹⁸F]fluoro-2-deoxytrehalose ([¹⁸F]FDT) - is a mechanism-based reporter of Mycobacteria-selective enzyme activity in vivo. Use of [^18</

SUBMITTER: Khan RMN 

PROVIDER: S-EPMC11211441 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature