Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain.

ABSTRACT:

Background

Convergence of Klebsiella pneumoniae (KP) pathotypes has been increasingly reported in recent years. These pathogens combine features of both multidrug-resistant and hypervirulent KP. However, clinically used indicators for hypervirulent KP identification, such as hypermucoviscosity, appear to be differentially expressed in convergent KP, potential outbreak clones are difficult to identify. We aimed to fill such knowledge gaps by investigating the temperature dependence of hypermucoviscosity and virulence in a convergent KP strain isolated during a clonal outbreak and belonging to the high-risk sequence type (ST)307.

Methods

Hypermucoviscosity, biofilm formation, and mortality rates in Galleria mellonella larvae were examined at different temperature

SUBMITTER: Muller JU 

PROVIDER: S-EPMC11211929 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature