Genetic correlation between smoking behavior and gastroesophageal reflux disease: insights from integrative multi-omics data.

ABSTRACT:

Background

Observational studies have preliminarily revealed an association between smoking and gastroesophageal reflux disease (GERD). However, little is known about the causal relationship and shared genetic architecture between the two. This study aims to explore their common genetic correlations by leveraging genome-wide association studies (GWAS) of smoking behavior-specifically, smoking initiation (SI), never smoking (NS), ever smoking (ES), cigarettes smoked per day (CPD), age of smoking initiation(ASI) and GERD.

Methods

Firstly, we conducted global cross-trait genetic correlation analysis and heritability estimation from summary statistics (HESS) to explore the genetic correlation between smoking behavior and GERD. Then, a joint cross-trait meta-analysis was performe

SUBMITTER: Yan Z 

PROVIDER: S-EPMC11212162 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature