Investigating diversity and similarity between CBM13 modules and ricin-B lectin domains using sequence similarity networks.

ABSTRACT:

Background

The CBM13 family comprises carbohydrate-binding modules that occur mainly in enzymes and in several ricin-B lectins. The ricin-B lectin domain resembles the CBM13 module to a large extent. Historically, ricin-B lectins and CBM13 proteins were considered completely distinct, despite their structural and functional similarities.

Results

In this data mining study, we investigate structural and functional similarities of these intertwined protein groups. Because of the high structural and functional similarities, and differences in nomenclature usage in several databases, confusion can arise. First, we demonstrate how public protein databases use different nomenclature systems to describe CBM13 modules and putative ricin-B lectin domains. We suggest the introduction o

SUBMITTER: De Coninck T 

PROVIDER: S-EPMC11212257 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature