The dynamics and longevity of circulating CD4 ⁺ memory T cells depend on cell age and not the chronological age of the host.

ABSTRACT: Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 ⁺ effector memory (T _EM ) and central memory (T _CM ) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. Here we address these issues by combining DNA labelling methods, established fate-mapping systems, a novel reporter mouse strain, and mathematical models. Together, these allow us to quantify the dynamics of both young and established circulating memory CD4 ⁺ T cell subsets, within both young and old mice. We show that that these cell

SUBMITTER: Bullock ME 

PROVIDER: S-EPMC11212895 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature