A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension.

ABSTRACT:

Background

Primary hypertension in childhood tracks into adulthood and may be associated with increased cardiovascular risk. Studies conducted in children and adolescents provide an opportunity to explore the early cardiovascular target organ injury (CV-TOI) in a population free from many of the comorbid cardiovascular disease risk factors that confound studies in adults.

Methods

Youths (n=132, mean age 15.8 years) were stratified by blood pressure (BP) as low, elevated, and high-BP and by left ventricular mass index (LVMI) as low- and high-LVMI. Systemic circulating RNA, miRNA, and methylation profiles in peripheral blood mononuclear cells and deep proteome profiles in serum were determined using high-throughput sequencing techniques.

Results

VASH1 gene expres

SUBMITTER: Ananthamohan K 

PROVIDER: S-EPMC11212900 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature