Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines.

ABSTRACT: Alcohol consumption produces acute analgesic effects, and people experiencing pain conditions may drink alcohol to alleviate discomfort. However, tolerance to the analgesic properties of alcohol could prompt escalating consumption and dependence. Both nociception and alcohol-induced analgesia are under significant genetic control. Understanding the genetic architecture of these processes could inform better treatment options for people with pain conditions. This study aims to identify quantitative trait loci (QTL) driving variation in ethanol-induced analgesia across BXD recombinant inbred mouse lines. Male and female mice from 62 BXD strains received ethanol or saline oral gavage for five days and were tested for hot plate (HP) latency at baseline, Day 1, and Day 5. QTL mapping of HP phen

SUBMITTER: Rogers WD 

PROVIDER: S-EPMC11212936 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature