Notch1 is required to maintain supporting cell identity and vestibular function during maturation of the mammalian balance organs.

ABSTRACT: The inner ear houses two sensory modalities: the hearing organ, located in the cochlea, and the balance organs, located throughout the vestibular regions of the ear. Both hearing and vestibular sensory regions are composed of similar cell types, including hair cells and associated supporting cells. Recently, we showed that Notch1 is required for maintaining supporting cell survival postnatally during cochlear maturation. However, it is not known whether Notch1 plays a similar role in the balance organs of the inner ear. To characterize the role of Notch during vestibular maturation, we conditionally deleted Notch1 from Sox2-expressing cells of the vestibular organs in the mouse at P0/P1. Histological analyses showed a dramatic loss of supporting cells accompanie

SUBMITTER: Heffer A 

PROVIDER: S-EPMC11212955 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature