Cell type-specific expression of angiotensin receptors in the human lung with implications for health, aging, and chronic disease.

ABSTRACT: The renin-angiotensin system is a highly characterized integrative pathway in mammalian homeostasis whose clinical spectrum has been expanded to lung disorders such as chronic obstructive pulmonary disease (COPD)-emphysema, idiopathic pulmonary fibrosis (IPF), and COVID pathogenesis. Despite this widespread interest, specific localization of this receptor family in the mammalian lung is limited, partially due to the imprecision of available antibody reagents. In this study, we establish the expression pattern of the two predominant angiotensin receptors in the human lung, AGTR1 and AGTR2, using complementary and comprehensive bulk and single-cell RNA-sequence datasets that are publicly available. We show these two receptors have distinct localization patterns and developmenta

SUBMITTER: Benjamin KJ 

PROVIDER: S-EPMC11212981 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature