Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling.

ABSTRACT: The balance of excitation and inhibition is a key functional property of cortical microcircuits which changes through the lifespan. Adolescence is considered a crucial period for the maturation of excitation-inhibition balance. This has been primarily observed in animal studies, yet human in vivo evidence on adolescent maturation of the excitation-inhibition balance at the individual level is limited. Here, we developed an individualized in vivo marker of regional excitation-inhibition balance in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional magnetic resonance imaging data from two independent cross-sectional (N = 752) and longitudinal (N = 149) cohorts. We found a widespread relative increase of in

SUBMITTER: Saberi A 

PROVIDER: S-EPMC11213014 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature