The association between rs6859 in NECTIN2 gene and Alzheimer's disease is partly mediated by pTau.

ABSTRACT:

Introduction

Emerging evidence suggests a connection between vulnerability to infections and Alzheimer's disease (AD). The nectin cell adhesion molecule 2 (NECTIN2) gene coding for a membrane component of adherens junctions is involved in response to infection, and its single nucleotide polymorphism (SNP) rs6859 was significantly associated with AD risk in several human cohorts. It is unclear, however, how exactly rs6859 influences the development of AD pathology. The aggregation of hyperphosphorylated tau protein (pTau) is a key pathological feature of neurodegeneration in AD, which may be induced by infections, among other factors, and potentially influenced by genes involved in both AD and vulnerability to infections, such as NECTIN2.

Materials and methods

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SUBMITTER: Rajendrakumar AL 

PROVIDER: S-EPMC11213054 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature