Functional dysconnectivity of visual and somatomotor networks yields a simple and robust biomarker for psychosis.

ABSTRACT: People with psychosis exhibit thalamo-cortical hyperconnectivity and cortico-cortical hypoconnectivity with sensory networks, however, it remains unclear if this applies to all sensory networks, whether it arises from other illness factors, or whether such differences could form the basis of a viable biomarker. To address the foregoing, we harnessed data from the Human Connectome Early Psychosis Project and computed resting-state functional connectivity (RSFC) matrices for 54 healthy controls and 105 psychosis patients. Primary visual, secondary visual ("visual2"), auditory, and somatomotor networks were defined via a recent brain network partition. RSFC was determined for 718 regions via regularized partial correlation. Psychosis patients- both affective and non-affective-exhibited cortic

SUBMITTER: Keane BP 

PROVIDER: S-EPMC11213076 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature