Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.

ABSTRACT: Low-intensity Transcranial Ultrasound Stimulation is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first collate a set of hypotheses on the directionality of TUS effects and conduct an initial meta-analysis on available healthy human participant TUS studies reporting stimulation parameters and outcomes (n = 47 studies, 52 experiments). In initial exploratory analyses with univariate tests, we find that parameters such as the intensity and continuity of stimulation (duty cycle) show statistical trends towards likely TUS neural enhancement or suppression of function. Machine-learning analyses were limi

SUBMITTER: Caffaratti H 

PROVIDER: S-EPMC11213082 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature