Characterizing hepatitis B virus infection in children in the Democratic Republic of Congo to inform elimination efforts.

ABSTRACT:

Objective

Despite global reductions in hepatitis B virus (HBV) prevalence, an estimated 6.2 million children are infected, two-thirds of whom live in the WHO Africa region. We sought to characterize childhood HBV to inform elimination efforts in the Democratic Republic of Congo (DRC), one of the largest and most populous African countries.

Methods

Using the most recent (2013-14) nationally representative Demographic and Health Survey in the DRC, we analyzed HBV surface antigen (HBsAg) on dried blood spots and associated survey data from children aged 6-59 months. We estimated HBsAg-positivity prevalence nationally, regionally, and by potential correlates of infection. We evaluated spatial variation in HBsAg-positivity prevalence, overall and by age, sex, and vaccination stat

SUBMITTER: Morgan CE 

PROVIDER: S-EPMC11213086 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature