Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology.

ABSTRACT: Plasma p-tau217 and Tau-PET are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In this head-to-head comparison study including 9 cohorts and 1534 individuals, we found that plasma p-tau217 and medial temporal lobe Tau-PET signal showed similar associations with cognitive decline on a global cognitive composite test (R² _PET=0.32 vs R² _PLASMA=0.32, p_difference=0.812) and with progression to mild cognitive impairment (Hazard ratio[HR]_PET=1.56[1.43-1.70] vs HR_PLASMA=1.63[1.50-1.77], p_difference=0.627). Combined plasma and PET models were superior to the single biomarker

SUBMITTER: Ossenkoppele R 

PROVIDER: S-EPMC11213114 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature