Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort.

ABSTRACT:

Objective

Neighborhood disadvantage is associated with worse health and cognitive outcomes. Morphological similarity network (MSN) is a promising approach to elucidate cortical network patterns underlying complex cognitive functions. We hypothesized that MSNs could capture intricate changes in cortical patterns related to neighborhood disadvantage and cognitive function, potentially explaining some of the risk for later life cognitive impairment among individuals who live in disadvantaged contexts.

Methods

This cross-sectional study included cognitively unimpaired participants (n=524, age=62.96±8.377, gender (M:F)=181:343, ADI(L:H) =450,74) from the Wisconsin Alzheimer's Disease Research Center or Wisconsin Registry for Alzheimer's Prevention. Neighborhood disadvantage statu

SUBMITTER: Safai A 

PROVIDER: S-EPMC11213155 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature