The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.

ABSTRACT: Ribosome heterogeneity has emerged as an important regulatory control feature for determining which proteins are synthesized, however, the influence of age on ribosome heterogeneity is not fully understood. Whether mRNA transcripts are selectively translated in young versus old cells and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified the 18S rRNA N6'-dimethyl adenosine (m^6,2A) methyltransferase, dimt-1, as a regulator of C. elegans lifespan and stress resistance. Lifespan extension induced by dimt-1 deficiency required a functional germline and was dependent on the known reg

SUBMITTER: Rothi MH 

PROVIDER: S-EPMC11213213 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature