Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma.

ABSTRACT: Solid carcinomas are often highly heterogenous cancers, arising from multiple epithelial cells of origin. Yet, how the cell of origin influences the response of the tumor microenvironment is poorly understood. Lung adenocarcinoma (LUAD) arises in the distal alveolar epithelium which is populated primarily by alveolar epithelial type I (AT1) and type II (AT2) cells. It has been previously reported that Gramd2 ⁺ AT1 cells can give rise to a histologically-defined LUAD that is distinct in pathology and transcriptomic identity from that arising from Sftpc ⁺ AT2 cells^1,2. To determine how cells of origin influence the tumor immune microenvironment (TIME) landscape, we comprehensively characterized transcriptomic, molecular, and cellular states with

SUBMITTER: Yang M 

PROVIDER: S-EPMC11213232 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature