Chlamydia trachomatis induces disassembly of the primary cilium to promote the intracellular infection.

ABSTRACT: Chlamydia trachomatis is a clinically important bacterium that infects epithelial cells of the genitourinary and respiratory tracts and the eye. These differentiated cells are in a quiescent growth state and have a surface organelle called a primary cilium, but the standard Chlamydia cell culture infection model uses cycling cells that lack primary cilia. To investigate if these differences are relevant, we performed infections with host cells that have a primary cilium. We found that C. trachomatis caused progressive loss of the primary cilium that was prevented by disrupting Aurora A (AurA), HDAC6 or calmodulin, which are components of the cellular cilia disassembly pathway. Stabilization of the primary cilium by targeting this pathway caused a large reduction in infectious progeny altho

SUBMITTER: Ekka R 

PROVIDER: S-EPMC11213297 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature