Molecular dynamics simulations of lipid-protein interactions in SLC4 proteins.

ABSTRACT: The SLC4 family of secondary bicarbonate transporters is responsible for the transport of HCO₃^-, CO₃^2-, Cl^-, Na⁺, K⁺, NH₃, and H⁺, which are necessary for regulation of pH and ion homeostasis. They are widely expressed in numerous tissues throughout the body and function in different cell types with different membrane properties. Potential lipid roles in SLC4 function have been reported in experimental studies, focusing mostly on two members of the family: AE1 (Cl^-/HCO₃^- exchanger) and NBCe1 (Na⁺-CO₃^2-cotransporter). Previous computational studies of the outward-facing state of AE1 with model lipid membranes revealed enhanced p

SUBMITTER: Zhekova HR 

PROVIDER: S-EPMC11214021 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature