The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer.

ABSTRACT:

Background

The transcription factor GATA4 is pivotal in cancer development but is often silenced through mechanisms like DNA methylation and histone modifications. This silencing suppresses the transcriptional activity of GATA4, disrupting its normal functions and promoting cancer progression. However, the precise molecular mechanisms and implications of GATA4 silencing in tumorigenesis remain unclear. Here, we aim to elucidate the mechanisms underlying GATA4 silencing and explore its role in breast cancer progression and its potential as a therapeutic target.

Methods

The GATA4-breast cancer prognosis link was explored via bioinformatics analyses, with GATA4 expression measured in breast tissues. Functional gain/loss experiments were performed to gauge GATA4's impact on brea

SUBMITTER: Yu W 

PROVIDER: S-EPMC11214403 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature