VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of bla_NDM-5 in zoonotic bacteria.

ABSTRACT: IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, bla_NDM-5, are rapidly spreading globally in both humans and animals. Given that carbapenems are listed on the WHO AWaRe watch group and are prohibited for use in animals, the drivers for the successful dissemination of Carbapenem-Resistant Enterobacterales (CRE) carrying bla_NDM-5-IncX3 plasmids still remain unknown. We observe that E. coli carrying bla_NDM-5-IncX3 can persist in chicken intestines either under the administration of amoxicillin, one of the largest veterinary β-lactams used in livestock, or without any antibiotic pressure. We therefore characterise the bla_NDM-5-IncX3 plasmid and identify a transcription regulator, VirBR, that binds to the promoter of the regula

SUBMITTER: Ma T 

PROVIDER: S-EPMC11214620 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature