Personalizing cardiovascular risk prediction for patients with systemic lupus erythematosus.

ABSTRACT:

Objective

Cardiovascular disease (CVD) risk is increased in SLE and underestimated by general population prediction algorithms. We aimed to develop a novel SLE-specific prediction tool, SLECRISK, to provide a more accurate estimate of CVD risk in SLE.

Methods

We studied patients in the Brigham and Women's Hospital SLE cohort. We collected one-year baseline data including the presence of traditional CVD factors and SLE-related features at cohort enrollment. Ten-year follow-up for the first major adverse cardiovascular event (MACE; myocardial infarction (MI), stroke, or cardiac death) began at day +1 following the baseline period (index date). ICD-9/10 codes identified MACE were adjudicated by board-certified cardiologists. Least absolute shrinkage and selection operator regre

SUBMITTER: Choi MY 

PROVIDER: S-EPMC11214838 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature