Assessment of Treatment Response in Patients With Severe Asthma Using Visual and Quantitative Analysis of Chest CT.

ABSTRACT:

Objective

To evaluate the role of visual and quantitative chest CT parameters in assessing treatment response in patients with severe asthma.

Materials and methods

Korean participants enrolled in a prospective multicenter study, named the Precision Medicine Intervention in Severe Asthma study, from May 2020 to August 2021, underwent baseline and follow-up chest CT scans (inspiration/expiration) 10-12 months apart, before and after biologic treatment. Two radiologists scored bronchiectasis severity and mucus plugging extent. Quantitative parameters were obtained from each CT scan as follows: normal lung area (normal), air trapping without emphysema (AT without emph), air trapping with emphysema (AT with emph), and airway (total branch count, Pi10). Clinical parameters, includ

SUBMITTER: Lee HN 

PROVIDER: S-EPMC11214920 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature