Scalable telomere-to-telomere assembly for diploid and polyploid genomes with double graph.

ABSTRACT: Despite advances in long-read sequencing technologies, constructing a near telomere-to-telomere assembly is still computationally demanding. Here we present hifiasm (UL), an efficient de novo assembly algorithm combining multiple sequencing technologies to scale up population-wide near telomere-to-telomere assemblies. Applied to 22 human and two plant genomes, our algorithm produces better diploid assemblies at a cost of an order of magnitude lower than existing methods, and it also works with polyploid genomes.

SUBMITTER: Cheng H 

PROVIDER: S-EPMC11214949 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature