Effects of chronic light cycle disruption during adolescence on circadian clock, neuronal activity rhythms, and behavior in mice.

ABSTRACT: The advent of artificial lighting, particularly during the evening and night, has significantly altered the predictable daily light and dark cycles in recent times. Altered light environments disrupt the biological clock and negatively impact mood and cognition. Although adolescents commonly experience chronic changes in light/dark cycles, our understanding of how the adolescents' brain adapts to altered light environments remains limited. Here, we investigated the impact of chronic light cycle disruption (LCD) during adolescence, exposing adolescent mice to 19 h of light and 5 h of darkness for 5 days and 12 L:12D for 2 days per week (LCD group) for 4 weeks. We showed that LCD exposure did not affect circadian locomotor activity but impaired memory and increased avoidance response in adol

SUBMITTER: Bonilla P 

PROVIDER: S-EPMC11215055 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature