Peripheral PD-1⁺NK cells could predict the 28-day mortality in sepsis patients.

ABSTRACT:

Background

Unbalanced inflammatory response is a critical feature of sepsis, a life-threatening condition with significant global health burdens. Immune dysfunction, particularly that involving different immune cells in peripheral blood, plays a crucial pathophysiological role and shows early warning signs in sepsis. The objective is to explore the relationship between sepsis and immune subpopulations in peripheral blood, and to identify patients with a higher risk of 28-day mortality based on immunological subtypes with machine-learning (ML) model.

Methods

Patients were enrolled according to the sepsis-3 criteria in this retrospective observational study, along with age- and sex-matched healthy controls (HCs). Data on clinical characteristics, laboratory tests, and lymphocy

SUBMITTER: Tang J 

PROVIDER: S-EPMC11215063 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature