Antiviral activity of temporin-1CEb analogues against gingival infection with herpes simplex virus type 1.

ABSTRACT:

Introduction

Oral herpes infections caused by herpes simplex virus type 1 (HSV-1) are one of the most common in the human population. Recently, they have been classified as an increasing problem in immunocompromised patients and those suffering from chronic inflammation of the oral mucosa and gums. Treatment mainly involves nucleoside analogues, such as acyclovir and its derivatives, which reduce virus replication and shedding. As drug-resistant strains of herpes emerge rapidly, there is a need for the development of novel anti-herpes agents. The aim of the study was to design an antiviral peptide, based on natural compounds, non-toxic to the host, and efficient against drug-resistant HSV-1. Here, we designed a lysine-rich derivative of amphibian temporin-1CEb conjugated to peptide

SUBMITTER: Golda A 

PROVIDER: S-EPMC11215077 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature