Performance of risk scores in predicting major bleeding in left ventricular assist device recipients: a comparative external validation.

ABSTRACT:

Background

Implantation of a left ventricular assist device (LVAD) is a crucial therapeutic option for selected end-stage heart failure patients. However, major bleeding (MB) complications postimplantation are a significant concern.

Objectives

We evaluated current risk scores' predictive accuracy for MB in LVAD recipients.

Methods

We conducted an observational, single-center study of LVAD recipients (HeartWare or HeartMate-3, November 2010-December 2022) in the Netherlands. The primary outcome was the first post-LVAD MB (according to the International Society on Thrombosis and Haemostasis [ISTH] and Interagency Registry for Mechanically Assisted Circulatory Support [INTERMACS], and INTERMACS combined with intracranial bleeding [INTERMACS+] criteria). Mortality prior t

SUBMITTER: van der Horst SFB 

PROVIDER: S-EPMC11215111 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature