An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures.

ABSTRACT:

Introduction

More than 350,000 chemicals make up the chemical universe that surrounds us every day. The impact of this vast array of compounds on our health is still poorly understood. Manufacturers are required to carry out toxicological studies, for example on the reproductive or nervous systems, before putting a new substance on the market. However, toxicological safety does not exclude effects resulting from chronic exposure to low doses or effects on other potentially affected organ systems. This is the case for the microbiome-immune interaction, which is not yet included in any safety studies.

Methods

A high-throughput in vitro model was used to elucidate the potential effects of environmental chemicals and chemical mixtures on microbiome-immune interactions. Therefore

SUBMITTER: Fischer F 

PROVIDER: S-EPMC11215145 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature