Durability of immunity and clinical protection in nursing home residents following bivalent SARS-CoV-2 vaccination.

ABSTRACT:

Background

Bivalent SARS-CoV-2 vaccines were developed to counter increasing susceptibility to emerging SARS-CoV-2 variants. We evaluated the durability of immunity and protection following first bivalent vaccination among nursing home residents.

Methods

We evaluated anti-spike and neutralization titers from blood in 653 community nursing home residents before and after each monovalent booster, and a bivalent vaccine. Concurrent clinical outcomes were evaluated using electronic health record data from a separate cohort of 3783 residents of Veterans Affairs (VA) nursing homes who had received at least the primary series monovalent vaccination. Using target trial emulation, we compared VA residents who did and did not receive the bivalent vaccine to measure vaccine effectivene

SUBMITTER: Gravenstein S 

PROVIDER: S-EPMC11215210 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature