UCP2 polymorphisms, daily step count, and number of teeth associated with all-cause mortality risk in Sado City: A hospital-based cohort study.

ABSTRACT:

Objective

Uncoupling protein 2 (UCP2) is an ion/anion transporter in the mitochondrial inner membrane that plays a crucial role in immune response, regulation of oxidative stress, and cellular metabolism. UCP2 polymorphisms are linked to chronic inflammation, obesity, diabetes, heart disease, exercise efficiency, and longevity. Daily step count and number of teeth are modifiable factors that reduce mortality risk, although the role of UCP2 in this mechanism is unknown. This study aimed to assess the possible effects of UCP2 polymorphisms on the association between daily step count and number of teeth with all-cause mortality.

Methods

This study was conducted as a cohort project involving adult Japanese outpatients at Sado General Hospital (PROST). The final number of partici

SUBMITTER: Lyu H 

PROVIDER: S-EPMC11215260 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature