Gene expression profiling of venous malformations identifies the role of SDC1 in venous endothelial cells.

ABSTRACT:

Objective

To obtain insight into the molecular process implicated in venous malformations (VMs) and identify potential targets for treatment of VMs, this study profiled the gene expression pattern in VMs, investigated alterations of syndecan-1 (SDC1) expression in VMs, and tested the hypothesis that aberrant SDC1 expression triggers abnormal angiogenesis and VM development.

Methods

Microarray analysis was performed to identify differentially expressed genes (DEGs) on a transcriptome-wide level in VMs and conjunctive normal. Gene Ontology molecular functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were carried out to establish enhancement of biological signaling pathways involved in VMs. Among the DEGs, we focused on SDC1, which is involved in m

SUBMITTER: Li J 

PROVIDER: S-EPMC11215287 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature