Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids.

ABSTRACT: Plasticity during the critical period is important for the functional maturation of cortical neurons. While characteristics of plasticity are diverse among cortical layers, it is unknown whether critical period timing is controlled by a common or unique molecular mechanism among them. We here clarified layer-specific regulation of the critical period timing of ocular dominance plasticity in the primary visual cortex. Mice lacking the endocannabinoid synthesis enzyme diacylglycerol lipase-α exhibited precocious critical period timing, earlier maturation of inhibitory synaptic function in layers 2/3 and 4, and impaired development of the binocular matching of orientation selectivity exclusively in layer 2/3. Activation of cannabinoid receptor restored ocular dominance plasticity at the norma

SUBMITTER: Yoneda T 

PROVIDER: S-EPMC11215304 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature