Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum.

ABSTRACT: Hydrogen sulfide (H₂S) has recently been recognized as an important gaseous transmitter with multiple physiological effects in various species. Previous studies have shown that H₂S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of Ganoderma lucidum. However, a comprehensive understanding of the physiological effects and molecular mechanisms of H₂S in G. lucidum remains unexplored. In this study, we found that heat treatment reduced the mitochondrial membrane potential (MMP) and mitochondrial DNA copy number (mtDNAcn) in G. lucidum. Increasing the intracellular H₂S concentration through pharmacological and genetic means increased the MMP level, mtDNAcn, oxygen consumption rate level and ATP content under hea

SUBMITTER: Shangguan J 

PROVIDER: S-EPMC11215418 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature