Functional Heterogeneity of Umbilical Cord Blood Monocyte-Derived Dendritic Cells.

ABSTRACT: Human umbilical cord blood (UCB) represents a unique resource for hematopoietic stem cell transplantation for children and patients lacking suitable donors. UCB harbors a diverse set of leukocytes such as professional APCs, including monocytes, that could act as a novel source for cellular therapies. However, the immunological properties of UCB monocytes and monocyte-derived dendritic cells (MoDCs) are not fully characterized. In this study, we characterized the phenotype and functions of UCB-MoDCs to gauge their potential for future applications. UCB exhibited higher frequencies of platelets and lymphocytes as well as lower frequencies of neutrophils in comparison with adult whole blood. Leukocyte subset evaluation revealed significantly lower frequencies of granulocytes, NK cells, and CD

SUBMITTER: Schweiger P 

PROVIDER: S-EPMC11215632 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature