Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC).

ABSTRACT:

Background

Cannabis is the most common illicit drug used in the USA and its use has been rising over the past decade, while the historical gap in rates of use between men and women has been decreasing. Sex differences in the effects of cannabinoids have been reported in animal models, but human studies are sparse and inconsistent. We investigated the sex differences in the acute subjective, psychotomimetic, cognitive, and physiological effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis.

Methods

Healthy male and female individuals, with limited exposure to cannabis, participated in a double blind, placebo-controlled study of intravenous (IV) placebo or THC at two doses (0.015 mg/kg and 0.03 mg/kg). Visual analog scale

SUBMITTER: Bassir Nia A 

PROVIDER: S-EPMC11215802 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature