Impacts of polyethylene glycol (PEG) dispersity on protein adsorption, pharmacokinetics, and biodistribution of PEGylated gold nanoparticles.

ABSTRACT: PEGylated gold nanoparticles (PEG-AuNPs) are widely used in drug delivery, imaging and diagnostics, therapeutics, and biosensing. However, the effect of PEG dispersity on the molecular weight (M _W) distribution of PEG grafted onto AuNP surfaces has been rarely reported. This study investigates the effect of PEG dispersity on the M _W distribution of PEG grafted onto AuNP surfaces and its subsequent impact on protein adsorption and pharmacokinetics, by modifying AuNPs with monodisperse PEG methyl ether thiols (mPEG _n -HS, n = 36, 45) and traditional polydisperse mPEG2k-SH (M _W = 1900). Polydisperse PEG-AuNPs favor the enrichment of lower M _W PEG fractions on their surface due to the steric hindra

SUBMITTER: Tian X 

PROVIDER: S-EPMC11216039 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature