Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis.

ABSTRACT: Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ cell genes during differentiation, and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. Surprisingly, we found that genome organization also contributes to NPC formation, mediated by the transcription factor Stonewall (Stwl). As GSCs differentiate, Stwl accumulates at boundaries between silenced and active gene compartments. Stwl at these boundaries plays a pivotal role in transitioning germ cell genes into a silenced state and ac

SUBMITTER: Kotb NM 

PROVIDER: S-EPMC11216175 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature