Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.

ABSTRACT: Cerebral oedema is associated with morbidity and mortality after traumatic brain injury (TBI)¹. Noradrenaline levels are increased after TBI^2-4, and the amplitude of the increase in noradrenaline predicts both the extent of injury⁵ and the likelihood of mortality⁶. Glymphatic impairment is both a feature of and a contributor to brain injury^7,8, but its relationship with the injury-associated surge in noradrenaline is unclear. Here we report that acute post-traumatic oedema results from a suppression of glymphatic and lymphatic fluid flow that occurs in response to excessive systemic release of noradrenaline. This post-TBI adrenergic storm was associated with reduced contractility of cervical lymphatic vessels, consistent with diminishe

SUBMITTER: Hussain R 

PROVIDER: S-EPMC11216305 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature