Association between tight junction proteins and cognitive performance in untreated persons with HIV.

ABSTRACT:

Background

HIV-associated neurocognitive disorders (HAND) still affects persons with HIV (PWH) and their pathogenesis is not completely understood. We aimed to explore the association between plasma and cerebrospinal fluid (CSF) markers of blood-brain barrier (BBB) impairment and HAND in untreated PWH.

Design

Cross-sectional study.

Methods

We enrolled untreated PWH, who underwent blood examinations and lumbar puncture to measure inflammation (IL-15, TNF-α), BBB damage (zonulin and tight junction proteins, tight junction proteins: occludin, claudin-5) and endothelial adhesion molecules (VCAM-1, ICAM-1). A comprehensive neurocognitive battery was used to diagnose HAND (Frascati criteria).

Results

Twenty-one patients (21/78, 26.9%) patients presented HAND (100% AN

SUBMITTER: Bai F 

PROVIDER: S-EPMC11216391 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature