TP53 mutations and the association with platinum resistance in high grade serous ovarian carcinoma.

ABSTRACT:

Objectives

Alterations in the tumor suppressor TP53 gene are the most common mutations in high grade serous ovarian carcinoma. The impact of TP53 mutations on clinical outcomes and platinum resistance is controversial. We sought to evaluate the genomic profile of high grade serous ovarian carcinoma and explore the association of TP53 mutations with platinum resistance.

Methods

Next generation sequencing data was obtained from our institutional database for patients with high grade serous ovarian carcinoma undergoing primary treatment. Sequencing data, demographic, and clinical information was reviewed. The primary outcome analyzed was time to recurrence or refractory diagnosis. Associations between the primary outcome and different classification schemes for TP53 mutations (

SUBMITTER: Montemorano L 

PROVIDER: S-EPMC11216889 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature