Dendritic cell-targeted delivery of antigens using extracellular vesicles for anti-cancer immunotherapy.

ABSTRACT: Neoantigen delivery using extracellular vesicles (EVs) has gained extensive interest in recent years. EVs derived from tumour cells or immune cells have been used to deliver tumour antigens or antitumor stimulation signals. However, potential DNA contamination from the host cell and the cost of large-scale EV production hinder their therapeutic applications in clinical settings. Here, we develop an antigen delivery platform for cancer vaccines from red blood cell-derived EVs (RBCEVs) targeting splenic DEC-205⁺ dendritic cells (DCs) to boost the antitumor effect. By loading ovalbumin (OVA) protein onto RBCEVs and delivering the protein to DCs, we were able to stimulate and present antigenic OVA peptide onto major histocompatibility complex (MHC) class I, subsequently priming acti

SUBMITTER: Dang XTT 

PROVIDER: S-EPMC11216926 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature