IPSC-derived cells stimulate ABCG2⁺/NES⁺ endogenous trabecular meshwork cell proliferation and tissue regeneration.

ABSTRACT: A major risk factor for glaucoma, the first leading cause of irreversible blindness worldwide, is the decellularisation of the trabecular meshwork (TM) in the conventional outflow pathway. Stem cell-based therapy, particularly the utilisation of induced pluripotent stem cells (iPSCs), presents an enticing potential for tissue regeneration and intraocular pressure (IOP) maintenance in glaucoma. We have previously observed that differentiated iPSCs can stimulate endogenous cell proliferation in the TM, a pivotal factor in TM regeneration and aqueous humour outflow restoration. In this study, we investigated the response of TM cells in vivo after interacting with iPSC-derived cells and identified two subpopulations responsible for this relatively long-term tissue regeneration: ATP Binding Cas

SUBMITTER: Xi G 

PROVIDER: S-EPMC11216930 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature