Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin.

ABSTRACT:

Background

The adiponectin is one of the rare adipokines down-regulated with obesity and protects against obesity-related disorders. Similarly, the apolipoprotein M (apoM) is expressed in adipocytes and its expression in adipose tissue is associated with metabolic health. We compared circulating apoM with adiponectin regarding their relationship with metabolic parameters and insulin sensitivity and examined their gene expression patterns in adipocytes and in the adipose tissue.

Methods

Circulating apoM and adiponectin were examined in 169 men with overweight in a cross-sectional study, and 13 patients with obesity during a surgery-induced slimming program. Correlations with clinical parameters including the insulin resistance index (HOMA-IR) were analyzed. Multiple regressio

SUBMITTER: Frances L 

PROVIDER: S-EPMC11216985 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature