Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1.

ABSTRACT:

Background/objective

Insulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined.

Subjects/methods

AdipoIR (in vivo adipose insulin resistance index) was measured in 2344 women and 787 men. In 259 of the women and 54 of the men, insulin induced inhibition of lipolysis (acylglycerol breakdown) and stimulation of lipogenesis (glucose conversion to acylglycerols) were determined in subcutaneous adipocytes; in addition, basal (spontaneous) lipolysis was also determined in the fat cells. In 234 women and 115 men, RNAseq expression of canonical insulin signal genes were measured in subcutaneous adipose tissue. Messenger RNA transcripts of the most discriminant genes were quantified in 175 women and 109 men.

Resul

SUBMITTER: Arner P 

PROVIDER: S-EPMC11217000 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature